A man and woman have been rushed to hospital following a serious crash on the Kwinana Freeway in Karnup.
Emergency services were called to the single vehicle crash near Paganoni Road around 11.15pm on Tuesday.
The RAC rescue helicopter airlifted the driver, a 45-year-old man, to Royal Perth Hospital with serious injuries.
A 24-year-old female passenger was also taken to Royal Perth Hospital by ambulance with serious injuries.
Police say inquiries are continuing into the crash.
The Kwinana Freeway was closed in both directions for over five hours causing major delays for motorists on Wednesday morning.
Southern suburbs electrician claims $1.8 million Lotto win
Works continue on Pinjarra's Munday Avenue extension
Halls Head support worker charged with historic child sex offences
Severe thunderstorm warning cancelled for Mandurah, Bunbury
Fortnightly red bin collections to remain in the City of Rockingham after council rejects motion
Rate rises on the way for Rockingham, Mandurah ratepayers
Harvey Police call on witnesses to serious crash
Men allegedly under the influence of alcohol when boat crashed under Mandurah Estuary Bridge
Works underway on 26 new social homes in Kwinana